My favorite bit is right at the beginning, when the real hand of the cartoonist reaches into the blank frame and begins to draw the opening scene.
As the Library of Congress describes:
"The films begin with 'out of the inkwell' drawings of the sort seen in Winsor McCay films and later elaborated by Max Fleischer. Like other comic strips and animated films of the era, notably Bringing Up Father (published from 1912; filmed 1916-18), Keeping Up with the Joneses features a husband oppressed by a wife’s obsession with high society and consumer fashion. The series ended abruptly in February 1916 after its animator, Harry S. Palmer, lost a patent infringement suit brought by John Randolph Bray over the use of transparent celluloid sheets."--Library of Congress.